Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027399 | 0.96 | ALDH1A1 (0.45) | CHRNB4CHRNA3ALDH1A1CYP3A4MEN1 | |
| SCHEMBL11457361 | 0.91 | CHRNB4 (0.54) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL11449248 | 0.87 | CHRNB4 (0.50) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL11457974 | 0.83 | CHRNB4 (0.49) | CHRNB4CHRNA3 | |
| SCHEMBL4018111 | 0.82 | NOS1 (0.44) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL11717555 | 0.82 | LTA4H (0.51) | CHEK2 | |
| SCHEMBL11455784 | 0.81 | CHRNB4 (0.52) | CHRNB4CHRNA3MEN1KMT2A | |
| SCHEMBL11712033 | 0.81 | CHRNB4 (0.47) | CHRNB4CHRNA3 | |
| SCHEMBL2172629 | 0.81 | CHRNB4 (0.51) | CHRNB4CHRNA3ALDH1A1MEN1KMT2A | |
| SCHEMBL7006966 | 0.81 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919892-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027527-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |