Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280493 | 0.85 | TNF (0.47) | TNFL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2278593 | 0.85 | TNF (0.47) | TNFL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2288486 | 0.84 | ATM (0.46) | TNFL3MBTL1POLBALDH1A1MEN1 | |
| SCHEMBL2168623 | 0.83 | MEN1 (0.54) | TNFPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL2282582 | 0.83 | MEN1 (0.54) | TNFPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL29790477 | 0.83 | MEN1 (0.54) | TNFPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL2282489 | 0.83 | MEN1 (0.54) | TNFPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL8534121 | 0.79 | TNF (0.49) | TNFPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL28680226 | 0.78 | TNF (0.56) | TNFL3MBTL1POLBALDH1A1MEN1 | |
| SCHEMBL7858417 | 0.77 | TNF (0.58) | TNFL3MBTL1POLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907373-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007005972-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |