Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568213 | 0.77 | ALDH1A1 (0.46) | TRPV4ENPP2TSHRALDH1A1MEN1 | |
| SCHEMBL976002 | 0.77 | MELK (0.39) | TRPV4MELKPIP4K2AALDH1A1MEN1 | |
| SCHEMBL30572420 | 0.71 | TRPV4 (0.41) | TRPV4TSHRALDH1A1AOC3 | |
| SCHEMBL17664048 | 0.71 | TRPV4 (0.48) | TRPV4S1PR3S1PR1 | |
| SCHEMBL8771796 | 0.70 | CA1 (0.51) | TSHRALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17588980 | 0.70 | TRPV4 (0.52) | TRPV4ENPP2ALDH1A1MEN1MAPT | |
| SCHEMBL15157689 | 0.70 | TRPV4 (0.40) | TRPV4TSHRMEN1MAPTKMT2A | |
| SCHEMBL2714212 | 0.69 | SCN9A (0.38) | SYKPIP4K2A | |
| SCHEMBL2714216 | 0.69 | SCN9A (0.38) | SYKPIP4K2A | |
| SCHEMBL24756413 | 0.69 | SYK (0.36) | SYKALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |