Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13561141 | 0.79 | HDAC1 (0.39) | MELKDGAT1ALDH1A1MAPTGAA | |
| SCHEMBL5027644 | 0.77 | TRPV4 (0.40) | MELKPIP4K2ATBK1ALDH1A1MAPT | |
| SCHEMBL5027778 | 0.74 | MELK (0.36) | MELKPIP4K2ATBK1ALDH1A1MAPT | |
| SCHEMBL977210 | 0.74 | PIP4K2A (0.39) | MELKPIP4K2AALDH1A1MAPTGAA | |
| SCHEMBL974622 | 0.71 | PIP4K2A (0.39) | MELKPIP4K2ATBK1ALDH1A1MAPT | |
| SCHEMBL974652 | 0.70 | TRPV4 (0.58) | DGAT1TRPV4MEN1KMT2A | |
| SCHEMBL28680437 | 0.67 | TRPV4 (0.35) | TDP1L3MBTL1TRPV4NPC1MEN1 | |
| SCHEMBL14139153 | 0.66 | HDAC1 (0.44) | DGAT1ALDH1A1MAPTGAAMEN1 | |
| SCHEMBL5026903 | 0.66 | F2 (0.36) | MELKTBK1ALDH1A1MAPTGAA | |
| SCHEMBL5989445 | 0.66 | ALDH1A1 (0.42) | MELKPIP4K2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664233-B2 | Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-03-04 | — | — | US | disclosed |
| US-8664233-B2 | Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-03-04 | — | — | US | disclosed |
| US-8664233-B2 | Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-03-04 | — | — | US | disclosed |
| EP-2104675-B1 | SUBSTITUTED 5H-PYRIMIDOL[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | MEDICINES CO LEIPZIG GMBH (DE) | 2012-10-31 | — | — | EP | disclosed |
| US-20110021511-A1 | SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| US-20110021511-A1 | SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| US-20110021511-A1 | SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| EP-2104675-A1 | SUBSTITUTED 5H-PYRIMIDOL[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | The Medicines Company (Leipzig) GmbH (DE) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008077631-A1 | SUBSTITUTED 5H-PYRIMIDOL[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021511-A1 | SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM | BCL6, BCL3, BCL6B | MELK 2168/4885PIP4K2A 1944/4885DGAT1 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.