Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | PGR | P06401 | 2/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12743862 | 0.97 | LMNA (0.69) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL545524 | 0.92 | HPGD (0.68) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL551152 | 0.91 | HPGD (0.66) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL9717125 | 0.90 | HPGD (0.60) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL10476884 | 0.90 | LMNA (0.69) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL7157287 | 0.90 | HPGD (0.63) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL126798 | 0.90 | GAA (0.65) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL29530425 | 0.90 | GAA (0.65) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL9717091 | 0.89 | HPGD (0.62) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL561993 | 0.88 | HPGD (0.68) | LMNAHPGDALDH1A1MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1895959-A1 | COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | CombinatoRx, Incorporated (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070110685-A1 | Combination therapy for the treatment of immunoinflammatory disorders | ZALICUS INC. | 2007-05-17 | — | — | US | disclosed |
| WO-2006138518-A1 | COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070110685-A1 | Combination therapy for the treatment of immunoinflammatory disorders | SERPINC1, SERPINA6, IL36G | LMNA 3750/4885HPGD 57/4885ALDH1A1 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.