Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 14/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.60 |
| ▸ | USP2 | O75604 | 7/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CCRL2 | O00421 | 5/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031899 | 0.87 | CCRL2 (0.50) | CYP1A2CYP3A4CLK4CYP2C19USP2 | |
| SCHEMBL5029207 | 0.87 | CYP1A2 (0.60) | CYP1A2CYP3A4CLK4CYP2C19USP2 | |
| SCHEMBL5027110 | 0.86 | CCRL2 (0.51) | CCRL2CCR2KCNH2IRAK4 | |
| SCHEMBL5027107 | 0.86 | CCRL2 (0.51) | CYP1A2CYP3A4CLK4CYP2C19USP2 | |
| SCHEMBL5027288 | 0.86 | CYP1A2 (0.61) | CYP1A2CYP3A4CLK4CYP2C19USP2 | |
| SCHEMBL5031903 | 0.86 | IRAK4 (0.55) | CYP1A2CYP3A4CLK4CYP2C19USP2 | |
| SCHEMBL5029621 | 0.83 | CCRL2 (0.52) | CCRL2CCR2KCNH2 | |
| SCHEMBL5027259 | 0.82 | CCRL2 (0.53) | CCRL2 | |
| SCHEMBL5033636 | 0.82 | CCRL2 (0.55) | CCRL2 | |
| SCHEMBL5029067 | 0.81 | CCRL2 (0.51) | CLK4CCRL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378409-B2 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-27 | — | — | US | disclosed |
| US-20050054626-A1 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054626-A1 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity | CCL11, CCR1, CCR2 | CYP1A2 2798/4885CYP3A4 3690/4885CLK4 4765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.