Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13375146 | 0.89 | ALDH1A1 (0.61) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL4240625 | 0.87 | ALDH1A1 (0.63) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL3268547 | 0.85 | HSD17B10 (0.54) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL12545719 | 0.84 | HSD17B10 (0.53) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL20178503 | 0.84 | LMNA (0.53) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL13375254 | 0.83 | ALDH1A1 (0.44) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL11374515 | 0.83 | HSD17B10 (0.51) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL15158071 | 0.81 | PRCP (0.48) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL19970799 | 0.79 | MAPK1 (0.41) | HSD17B10KDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL4241945 | 0.78 | MAPT (0.51) | HSD17B10KDM4ELMNAALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993536-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| US-4243806-A | ANTIALLERGENS; ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-06 | — | — | US | disclosed |
| US-4179505-A | ANTIALLERGENS; ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |