Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 3/20 | 0.39 |
| ▸ | ALPI | P09923 | 2/20 | 0.39 |
| ▸ | ALPG | P10696 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13034836 | 0.87 | ALDH1A1 (0.59) | LMNAHSD17B10KDM4EALDH1A1ALOX15 | |
| SCHEMBL3268547 | 0.85 | HSD17B10 (0.54) | LMNAHSD17B10KDM4EALDH1A1ALOX15 | |
| SCHEMBL12545719 | 0.84 | HSD17B10 (0.53) | LMNAHSD17B10KDM4EALDH1A1ALOX15 | |
| SCHEMBL5029652 | 0.84 | HSD17B10 (0.53) | LMNAHSD17B10KDM4EALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL11374515 | 0.83 | HSD17B10 (0.51) | LMNAHSD17B10KDM4EALDH1A1ALOX15 | |
| SCHEMBL18656067 | 0.82 | MAPT (0.55) | LMNAKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL23800775 | 0.81 | XDH (0.50) | KDM4EALDH1A1ALOX15TAAR1KMT2A | |
| SCHEMBL23718641 | 0.81 | KDM4E (0.43) | LMNAHSD17B10KDM4EALDH1A1ALOX15 | |
| SCHEMBL9296249 | 0.79 | SLC2A1 (0.46) | HSD17B10KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL21676250 | 0.78 | CYP1A2 (0.51) | LMNAHSD17B10KDM4EALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY (US) | 2023-08-22 | — | — | US | disclosed |
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | UNIV CORNELL (US) | 2022-02-24 | — | — | US | disclosed |
| US-11203613-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY | 2021-12-21 | — | — | US | disclosed |
| US-20200317729-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | CORNELL UNIVERSITY | 2020-10-08 | — | — | US | disclosed |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317729-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | PSMB1, PSMB3, PSMB11 | LMNA 3672/4885HSD17B10 4401/4885KDM4E 1197/4885 |
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | PSMB1, PSMB3, PSMB11 | LMNA 3663/4885HSD17B10 4404/4885KDM4E 1196/4885 |
| US-11203613-B2 | Peptidomimetic proteasome inhibitors | PSMB1, PSMB3, PSMB11 | LMNA 3672/4885HSD17B10 4401/4885KDM4E 1197/4885 |
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | PSMB1, PSMB3, PSMB11 | LMNA 3663/4885HSD17B10 4404/4885KDM4E 1196/4885 |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | LMNA 4211/4885HSD17B10 836/4885KDM4E 4005/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | LMNA 4211/4885HSD17B10 836/4885KDM4E 4005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.