Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 11/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | CPB1 | P15086 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029365 | 0.89 | ALDH1A1 (0.46) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL5029150 | 0.78 | ALDH1A1 (0.55) | ALDH1A1CCR2CYP3A4TSHRCCR3 | |
| SCHEMBL5029161 | 0.78 | ALDH1A1 (0.55) | ALDH1A1CCR2CYP3A4TSHRCCR3 | |
| SCHEMBL5030306 | 0.77 | CCR2 (0.33) | CCR2CYP2D6KCNH2 | |
| SCHEMBL5033696 | 0.77 | CCR2 (0.61) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL5033692 | 0.77 | CCR2 (0.61) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL5031889 | 0.75 | ALDH1A1 (0.47) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL5031885 | 0.75 | ALDH1A1 (0.47) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL5029286 | 0.74 | ALDH1A1 (0.52) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL5029665 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CCR2CYP2D6KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378409-B2 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-27 | — | — | US | disclosed |
| US-20050054626-A1 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054626-A1 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity | CCL11, CCR1, CCR2 | ALDH1A1 827/4885CCR2 3/4885CYP2D6 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.