SCHEMBL5029966

SCHEMBL5029966

Clc1cccc(Cl)c1[Si](Cl)(Cl)Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.45
CYP2A6 P11509 2/20 0.45
TSHR P16473 4/20 0.44
LMNA P02545 2/20 0.44
ALDH1A1 P00352 4/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
ADRA2A P08913 2/20 0.35
ADRA2C P18825 2/20 0.35
ADRA1D P25100 2/20 0.35
ADRA1A P35348 2/20 0.35
ADRA1B P35368 2/20 0.35
TAAR1 Q96RJ0 1/20 0.35
PNMT P11086 1/20 0.35
NR4A2 P43354 1/20 0.35
NOS1 P29475 2/20 0.34
CYP3A4 P08684 1/20 0.33
SLC22A1 O15245 1/20 0.33
SLC22A3 O75751 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12188521 0.73 CYP1A2 (0.43) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL2103502 0.69 TSHR (0.44) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL5031009 0.67 CYP2A6 (0.43) CYP1A2CYP2A6TSHRALDH1A1TDP1
SCHEMBL1225074 0.67 TSHR (0.50) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL3991309 0.65 TSHR (0.61) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL23239 0.65
SCHEMBL2471569 0.65 TSHR (0.57) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL1686581 0.65 ADRA2A (0.52) CYP1A2CYP2A6TSHRLMNAMEN1
SCHEMBL24125843 0.64 HSD11B1 (0.38) CYP1A2CYP2A6TSHRLMNAALDH1A1
1,2-Dichlorobenzene SCHEMBL5190 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101472959-A Ziegler-Natta catalyst with in situ-generated donor NOVOLEN TECH HOLDINGS CV (NL) 2009-07-01 CN disclosed
EP-1999167-A2 ZIEGLER-NATTA CATALYST WITH IN SITU-GENERATED DONOR Novolen Technology Holdings, C.V. (NL) 2008-12-10 EP disclosed
WO-2007106348-A2 ZIEGLER-NATTA CATALYST WITH IN SITU-GENERATED DONOR NOVOLEN TECHNOLOGY HOLDINGS C.V. (NL) 2007-09-20 WO disclosed
US-20070213204-A1 Ziegler-Natta catalyst with in situ-generated donor NOVOLEN TECHNOLOGY HOLDINGS C.V. 2007-09-13 US disclosed