Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | MMP2 | P08253 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380370 | 0.88 | MMP2 (0.53) | SMN1; SMN2ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL1376078 | 0.85 | MMP13 (0.56) | SMN1; SMN2ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL30461756 | 0.78 | MEN1 (0.56) | SMN1; SMN2ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL30461745 | 0.78 | MEN1 (0.56) | SMN1; SMN2ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL30461742 | 0.76 | MEN1 (0.54) | SMN1; SMN2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL30461760 | 0.75 | KMT2A (0.53) | SMN1; SMN2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL6723629 | 0.73 | MMP2 (0.56) | ADAMTS4LMNAMMP13MMP2MMP3 | |
| SCHEMBL22500424 | 0.73 | MEN1 (0.69) | SMN1; SMN2ALDH1A1KMT2AMEN1ADAM33 | |
| SCHEMBL22500423 | 0.73 | MEN1 (0.69) | SMN1; SMN2ALDH1A1KMT2AMEN1ADAM33 | |
| SCHEMBL5031605 | 0.73 | KLK7 (0.51) | KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |
| EP-1053226-A1 | SULFONYLAMINO DERIVATIVES WHICH INHIBIT MATRIX-DEGRADING METALLOPROTEINASES | Novartis AG (CH) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999042443-A1 | SULFONYLAMINO DERIVATIVES WHICH INHIBIT MATRIX-DEGRADING METALLOPROTEINASES | NOVARTIS AG (CH) | 1999-08-26 | — | — | WO | disclosed |