Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 3/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25716962 | 1.00 | KLK7 (0.51) | KLK7KLK5MEN1KMT2ANPSR1 | |
| SCHEMBL25715442 | 0.91 | CTSL (0.54) | KLK7KLK5CACNA1BPPARACTSL | |
| SCHEMBL19390152 | 0.90 | ITGB3 (0.49) | KLK7KLK5MEN1KMT2ANPSR1 | |
| SCHEMBL10058277 | 0.90 | ITGB3 (0.49) | KLK7KLK5MEN1KMT2ANPSR1 | |
| SCHEMBL13687946 | 0.90 | ITGB3 (0.49) | KLK7KLK5MEN1KMT2ANPSR1 | |
| SCHEMBL25716006 | 0.90 | CTSL (0.56) | KLK7KLK5CACNA1BPPARACTSL | |
| SCHEMBL13340589 | 0.86 | KLK7 (0.49) | KLK7KLK5MEN1KMT2ANPSR1 | |
| SCHEMBL30461760 | 0.84 | KMT2A (0.53) | MEN1KMT2ANPSR1CTSS | |
| SCHEMBL10164382 | 0.84 | SIRT2 (0.48) | KLK7KLK5MEN1KMT2ANPSR1 | |
| SCHEMBL7420017 | 0.82 | MEN1 (0.46) | MEN1KMT2ANPSR1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059213-A1 | LONP1 INHIBITORS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2025-02-20 | — | — | US | disclosed |
| US-20250059214-A1 | AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2025-02-20 | — | — | US | disclosed |
| EP-4444726-A1 | LONP1 INHIBITORS, USES AND METHODS | Pretzel Therapeutics, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| EP-4444727-A1 | AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | Pretzel Therapeutics, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107470-A1 | LONP1 INHIBITORS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107481-A1 | AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107470-A1 | LONP1 INHIBITORS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107481-A1 | AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059213-A1 | LONP1 INHIBITORS, USES AND METHODS | LONP1, ACAT1, ACAA2 | KLK7 4039/4885KLK5 3609/4885MEN1 3542/4885 |
| US-20250059214-A1 | AMIDE-CONTAINING LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | LONP1, ACAT1, ACAA2 | KLK7 4446/4885KLK5 4114/4885MEN1 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.