Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18918957 | 0.87 | MMP2 (0.46) | MMP2MMP9MMP3MMP13KMT2A | |
| SCHEMBL442293 | 0.85 | MMP2 (0.44) | MMP2MMP9MMP3MMP13KMT2A | |
| SCHEMBL6738589 | 0.84 | ELANE (0.47) | MMP2MMP9MMP3MMP13KMT2A | |
| SCHEMBL6389343 | 0.84 | ELANE (0.47) | MMP2MMP9MMP3MMP13KMT2A | |
| Hydrochloric Acid SCHEMBL6971175 | 0.83 | ELANE (0.49) | MMP2MMP9MMP3MMP13KMT2A | |
| Hydrochloric Acid SCHEMBL6971183 | 0.83 | ELANE (0.49) | MMP2MMP9MMP3MMP13KMT2A | |
| SCHEMBL29166106 | 0.82 | HDAC7 (0.53) | KMT2AMEN1HSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL6291909 | 0.81 | PKM (0.47) | MMP2MMP9HSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL9322023 | 0.81 | HDAC1 (0.47) | KMT2AMEN1HSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL11083101 | 0.81 | ALDH1A1 (0.48) | MMP2MMP9MMP3MMP13KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |