SCHEMBL5031733

SCHEMBL5031733

CCCOc1ccc(COC(=O)NCc2cc(CC3(C(=O)O)CCCO3)ccc2OCC)cc1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NAAA Q02083 1/20 0.39
ASAH1 Q13510 1/20 0.39
PPARG P37231 14/20 0.36
PPARA Q07869 11/20 0.36
TSHR P16473 1/20 0.36
FAAH O00519 1/20 0.35
HRH3 Q9Y5N1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5031917 0.95 L3MBTL1 (0.37) MAPTL3MBTL1PPARGPPARA
SCHEMBL5031929 0.91 PPARA (0.36) PPARGPPARATSHR
SCHEMBL5031746 0.90 PPARG (0.41) L3MBTL1PPARGPPARA
SCHEMBL5029863 0.90 RAB9A (0.36) MAPTL3MBTL1PPARGPPARA
SCHEMBL5029893 0.89 PPARG (0.36) L3MBTL1NAAAASAH1PPARGPPARA
SCHEMBL5031971 0.89 PPARA (0.39) MAPTL3MBTL1PPARGPPARA
SCHEMBL5140241 0.89 PPARG (0.46) PPARGPPARA
SCHEMBL5032869 0.89 PPARG (0.46) PPARGPPARA
SCHEMBL5139405 0.89 PPARG (0.46) PPARGPPARA
SCHEMBL5036977 0.88 OPRM1 (0.35) L3MBTL1PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7371777-B2 Cyclic compound and PPAR agonist EISAI CO., LTD. (JP) 2008-05-13 US disclosed
US-7371777-B2 Cyclic compound and PPAR agonist EISAI CO., LTD. (JP) 2008-05-13 US disclosed
US-7371777-B2 Cyclic compound and PPAR agonist EISAI CO., LTD. (JP) 2008-05-13 US disclosed
US-20050014833-A1 Cyclic compound and ppar agonist EISAI R&D MANAGEMENT CO., LTD. (JP) 2005-01-20 US disclosed
EP-1452521-A1 CYCLIC COMPOUND AND PPAR AGONIST Eisai Co., Ltd. (JP) 2004-09-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014833-A1 Cyclic compound and ppar agonist PPARA, PPARG, PPARD MAPT 4663/4885L3MBTL1 2870/4885NAAA 2178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.