Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302030 | 0.86 | HRH3 (0.33) | HRH3CYP1A2CYP2D6CYP4F2CYP4A11 | |
| SCHEMBL2655437 | 0.81 | FFAR1 (0.36) | PDE1BNPC1RAB9APOLBEGLN1 | |
| SCHEMBL3916037 | 0.81 | NPC1 (0.40) | PDE1BNPC1RAB9APOLBPIK3CD | |
| SCHEMBL14829629 | 0.80 | MCHR1 (0.38) | CYP4A11PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL7841404 | 0.75 | PDE1B (0.39) | PDE1BPOLB | |
| SCHEMBL504022 | 0.74 | HRH3 (0.56) | HRH3NPC1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL3913707 | 0.74 | PDE1B (0.33) | PDE1BPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL2644223 | 0.73 | GABRP (0.43) | PDE1B | |
| SCHEMBL28801464 | 0.73 | ALDH1A1 (0.49) | NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL16892170 | 0.73 | NPC1 (0.41) | HRH3NPC1RAB9ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1916239-A1 | PYRIDONE COMPOUND | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-30 | — | — | EP | disclosed |
| EP-0579733-B1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | UPJOHN CO (US) | 2001-06-20 | — | — | EP | disclosed |
| US-5441971-A | Antidiabetic agents | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0579733-A1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | PHARMACIA & UPJOHN COMPANY (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992018501-A1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |