Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19271810 | 0.95 | NOS3 (0.43) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL33526075 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL6088399 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL10633018 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL1954285 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL868782 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL8031217 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL867932 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL10427141 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 | |
| SCHEMBL4941511 | 0.93 | NOS3 (0.42) | NOS3NOS1DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953158-B1 | BICYCLIC CINNAMIDE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-12 | — | — | EP | claimed |
| US-20230067929-A1 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF CANCER | TOLREMO THERAPEUTICS AG (CH) | 2023-03-02 | — | — | US | disclosed |
| US-9981968-B2 | Substituted pyrrolo[2,3-d]pyrimidines for the treatment of cancer and proliferative disorders | NORTHWESTERN UNIVERSITY (US) | 2018-05-29 | — | — | US | disclosed |
| EP-1953158-B1 | BICYCLIC CINNAMIDE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-12 | — | — | EP | disclosed |
| US-20110237538-A1 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES | SUMMIT CORPORATION PLC (GB) | 2011-09-29 | — | — | US | disclosed |
| US-20110237538-A1 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES | SUMMIT CORPORATION PLC (GB) | 2011-09-29 | — | — | US | disclosed |
| US-20110195929-A1 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS | SUMMIT CORPORATION PLC (GB) | 2011-08-11 | — | — | US | disclosed |
| US-20110195929-A1 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS | SUMMIT CORPORATION PLC (GB) | 2011-08-11 | — | — | US | disclosed |
| EP-1953158-A1 | BICYCLIC CINNAMIDE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-0693068-B1 | PHENYLPYRROLE DERIVATIVES AND THEIR USE AS ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-07-29 | — | — | EP | disclosed |
| US-5688790-A | Phenylpyrrole derivatives and their use as antipsychotic agents | SMITHKLINE BEECHAM PLC (GB) | 1997-11-18 | — | — | US | disclosed |
| EP-0710237-A1 | QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-05-08 | — | — | EP | disclosed |
| EP-0693068-A1 | PHENYLPYRROLE DERIVATIVES AND THEIR USE AS ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1996-01-24 | — | — | EP | disclosed |
| WO-1995003302-A1 | QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-02-02 | — | — | WO | disclosed |
| WO-1994024129-A1 | PHENYLPYRROLE DERIVATIVES AND THEIR USE AS ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237538-A1 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES | GAA, MAN2B1, GBA1 | NOS3 4107/4885NOS1 4051/4885DPP4 1074/4885 |
| US-20110195929-A1 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS | GPI, GALE, HAVCR2 | NOS3 4046/4885NOS1 4102/4885DPP4 265/4885 |
| US-20230067929-A1 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF CANCER | SLC10A1, SLC6A6, SLC10A6 | NOS3 2479/4885NOS1 2882/4885DPP4 2425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.