SLC6A6

Sodium- and chloride-dependent taurine transporter · P31641 · SLC6A6 on Sugi Atlas →

1,038 patent compounds predicted against SLC6A6, 698 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Taurine Taurine (SCHEMBL42632) 1.00 1/20
Taurine Taurine (SCHEMBL3480915) 0.93 1/20
Taurine Taurine (SCHEMBL8052521) 0.93 1/20
Taurine Taurine (SCHEMBL628769) 0.88 1/20
Taurine Taurine (SCHEMBL6363956) 0.88 1/20
Taurine Taurine (SCHEMBL16859744) 0.88 1/20
Taurine Taurine (SCHEMBL27565800) 0.88 1/20
Taurine Taurine (SCHEMBL28149270) 0.88 1/20
Taurine Taurine (SCHEMBL28338183) 0.88 1/20
Taurine Taurine (SCHEMBL1268510) 0.82 1/20
Taurine Taurine (SCHEMBL1826395) 0.82 1/20
Taurine Taurine (SCHEMBL4449607) 0.82 1/20
Taurine Taurine (SCHEMBL7213501) 0.82 1/20
Taurine Taurine (SCHEMBL8508635) 0.82 1/20
Taurine Taurine (SCHEMBL8698527) 0.82 1/20
Taurine Taurine (SCHEMBL9112233) 0.82 1/20
Taurine Taurine (SCHEMBL11026626) 0.82 1/20
Taurine Taurine (SCHEMBL15531654) 0.82 1/20
Taurine Taurine (SCHEMBL2577074) 0.78 1/20
Taurine Taurine (SCHEMBL3451913) 0.78 1/20

Clinical trials — most relevant to SLC6A6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS) PHASE4COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis PHASE2COMPLETED
Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin PHASE2NOT_YET_RECRUITING
Effect of, OAT3, on the Renal Secretion of Cefotaxime PHASE1COMPLETED
Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1 PHASE1COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure EARLY_PHASE1COMPLETED
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure EARLY_PHASE1COMPLETED
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS nanCOMPLETED
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS nanNOT_YET_RECRUITING
SLC6A1-NDD Prospective Longitudinal Natural History Study nanNOT_YET_RECRUITING
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
Bile Acid Effects in Fetal Arrhythmia Study nanUNKNOWN
Oxalate and Citrate nanRECRUITING
SLC13A5 Deficiency Natural History Study - Remote Only nanENROLLING_BY_INVITATION
Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management nanUNKNOWN
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Impact of Genetics on Metformin Pharmacokinetics nanCOMPLETED
Sodium Transport: Genetics and Hypertension nanCOMPLETED
Renal Transporters After Renal Transplantation nanUNKNOWN
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs nanCOMPLETED
Identifying Diuretic Resistance in Patients With Acute Heart Failure nanCOMPLETED
Evaluation of Renal Function in Patients With Hyperthyroidism nanNOT_YET_RECRUITING
Effect of an Polyphenolic Beverage in Healthy Volunteers nanACTIVE_NOT_RECRUITING
Stem Cell Study of Genetics and Drug Addiction nanCOMPLETED
SLC13A5 Deficiency Natural History Study - United States Only nanENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a SLC6A6 binder may also engage these)

ProteinNameSimilarity
O35316 1.000 O35316 →
P31649 1.000 P31649 →
P31646 1.000 P31646 →
SLC6A4 Sodium-dependent serotonin transporter 1.000 landscape →
SLC6A11 Sodium- and chloride-dependent GABA transporter 3 1.000 landscape →
Q9MZ34 1.000 Q9MZ34 →
Q9MYX0 1.000 Q9MYX0 →
Q00589 1.000 Q00589 →
Q03614 1.000 Q03614 →
P31652 1.000 P31652 →
O18875 1.000 O18875 →
P31647 1.000 P31647 →
Q61327 1.000 Q61327 →
SLC6A13 Sodium- and chloride-dependent GABA transporter 2 1.000 landscape →
P23977 1.000 P23977 →
P31643 1.000 P31643 →
O88575 1.000 O88575 →
P31650 1.000 P31650 →
P48057 1.000 P48057 →
P51905 1.000 P51905 →
Q9UN76 1.000 Q9UN76 →
P48029 1.000 P48029 →
P28572 1.000 P28572 →
P51143 1.000 P51143 →
P31651 1.000 P31651 →
Q9XT49 1.000 Q9XT49 →
P48056 1.000 P48056 →
P28570 1.000 P28570 →
B4JMC1 1.000 B4JMC1 →
P31661 1.000 P31661 →