Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772015 | 0.80 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8818379 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL28786587 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL369489 | 0.77 | ALDH1A1 (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL1437509 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL20534000 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL18626491 | 0.77 | ALOX15 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL21238310 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL28786529 | 0.75 | HPGD (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL12408070 | 0.74 | KDM6B (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896040-A2 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | Threshold Pharmaceuticals, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007002931-A2 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |