Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035874 | 0.93 | KDM4E (0.40) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5032531 | 0.93 | KDM4E (0.41) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5035132 | 0.91 | KDM4E (0.45) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5486463 | 0.90 | CYP3A4 (0.49) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5034815 | 0.89 | KDM4E (0.43) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5032616 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5039367 | 0.86 | KDM4E (0.41) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL5032626 | 0.85 | CYP3A4 (0.47) | ALDH1A1KDM4EHTTMAPTSMN1; SMN2 | |
| SCHEMBL6488544 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4EHTTNPSR1MAPT | |
| SCHEMBL14190174 | 0.83 | CYP3A4 (0.48) | ALDH1A1HTTMAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |