Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035190 | 0.87 | MAPT (0.49) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5034815 | 0.86 | KDM4E (0.43) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5032555 | 0.83 | ALDH1A1 (0.44) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5032531 | 0.82 | KDM4E (0.41) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5032616 | 0.82 | KDM4E (0.41) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL27664671 | 0.82 | MAPT (0.39) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5038951 | 0.82 | KDM4E (0.43) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5034980 | 0.81 | KDM4E (0.47) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5035874 | 0.81 | KDM4E (0.40) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5035132 | 0.80 | KDM4E (0.45) | ALDH1A1RAB9AHTTNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153962-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153962-A1 | Thiazole derivatives | CNR1, CNR2, GPR119 | ALDH1A1 473/4885RAB9A 1847/4885HTT 1466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.