Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | NAMPT | P43490 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032437 | 0.88 | HDAC2 (0.73) | SMN1; SMN2LMNAHTTHDAC2HDAC8 | |
| SCHEMBL5035260 | 0.87 | AKR1C3 (0.63) | SMN1; SMN2LMNAHTTHDAC2HDAC8 | |
| SCHEMBL2850006 | 0.86 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAHTTHDAC2HDAC8 | |
| SCHEMBL5032594 | 0.81 | CYP19A1 (0.73) | SMN1; SMN2LMNANAMPTHTTRAB9A | |
| SCHEMBL5034915 | 0.80 | L3MBTL1 (0.60) | SMN1; SMN2LMNANPC1ALDH1A1 | |
| SCHEMBL5034887 | 0.79 | CYP2C19 (0.76) | HTTHDAC2HDAC8HDAC6PKM | |
| SCHEMBL17372930 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNANAMPTHTTRAB9A | |
| SCHEMBL2850555 | 0.77 | LMNA (0.53) | SMN1; SMN2LMNAHTTHDAC2HDAC8 | |
| SCHEMBL4662893 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNANAMPTHTTRAB9A | |
| SCHEMBL4070835 | 0.76 | HDAC2 (0.77) | SMN1; SMN2LMNAHTTHDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378417-B2 | Pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | disclosed |
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |