Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 17/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032572 | 0.93 | KIF18A (0.45) | KIF18AKDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5041408 | 0.92 | KIF18A (0.45) | KIF18AKDM4EHTTKMT2A | |
| SCHEMBL5035239 | 0.90 | KIF18A (0.48) | KIF18AKDM4EHTTKMT2A | |
| SCHEMBL5035007 | 0.89 | NTRK1 (0.41) | KDM4EHTTKMT2AMAPK1RORC | |
| SCHEMBL5035231 | 0.89 | KIF18A (0.35) | KIF18AKDM4EHTTKMT2A | |
| SCHEMBL5045480 | 0.88 | KIF18A (0.51) | KIF18AKDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5039141 | 0.88 | KDM4E (0.49) | KIF18AKDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5036088 | 0.87 | CA12 (0.42) | KDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5039084 | 0.85 | KIF18A (0.44) | KIF18AKDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5041449 | 0.85 | KIF18A (0.46) | KIF18AKDM4EHTTKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |