Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032617 | 0.93 | TP53 (0.36) | KIF18AALDH1A1KMT2AKDM4ECA12 | |
| SCHEMBL5034987 | 0.90 | KDM4E (0.41) | KIF18AALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL5032665 | 0.89 | KIF18A (0.46) | KIF18AKMT2AKDM4EHTT | |
| SCHEMBL5045719 | 0.89 | POLB (0.44) | KIF18AALDH1A1KMT2AKDM4EPLAT | |
| SCHEMBL5032676 | 0.88 | ALDH1A1 (0.45) | KIF18AALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL5041458 | 0.82 | ALDH1A1 (0.40) | KIF18AALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL5032572 | 0.81 | KIF18A (0.45) | KIF18AKMT2AKDM4EHTT | |
| SCHEMBL5041408 | 0.81 | KIF18A (0.45) | KIF18AKMT2AKDM4EHTT | |
| SCHEMBL5045196 | 0.81 | POLB (0.49) | KIF18AALDH1A1KMT2AKDM4EPLAT | |
| SCHEMBL5034997 | 0.81 | KDM4E (0.41) | KIF18AALDH1A1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |