Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP9 | P14780 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974105 | 0.82 | LMNA (0.46) | LMNAMMP2MMP9MMP3TP53 | |
| SCHEMBL15212094 | 0.78 | LMNA (0.48) | LMNAMMP2MMP9MMP3TP53 | |
| SCHEMBL2850139 | 0.74 | MMP2 (0.45) | LMNAMMP2MMP9MMP3ALDH1A1 | |
| SCHEMBL8348835 | 0.72 | LMNA (0.59) | LMNAMMP2MMP9MMP3TP53 | |
| Hydrochloric Acid SCHEMBL16822147 | 0.68 | PDK2 (0.53) | LMNAALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3967648 | 0.67 | MMP2 (0.36) | LMNAMMP2MMP9TP53ALDH1A1 | |
| SCHEMBL9694966 | 0.66 | LMNA (0.61) | LMNAMMP2MMP9MMP3TP53 | |
| SCHEMBL17169741 | 0.66 | LMNA (0.43) | LMNAMMP2MMP9MMP3TP53 | |
| Hydrochloric Acid SCHEMBL9694949 | 0.64 | LMNA (0.59) | LMNAMMP2MMP9MMP3TP53 | |
| Dimethylbarbiturate SCHEMBL296700 | 0.64 | LMNA (0.48) | LMNAMMP2MMP9MMP3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004614-A1 | TETRAHALOGENATED COMPOUNDS USEFUL AS INHIBITORS OF ANGIOGENESIS | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120669-A1 | TETRAHALOGENATED COMPOUNDS USEFUL AS INHIBITORS OF ANGIOGENESIS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-10-25 | — | — | WO | disclosed |