Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033291 | 0.90 | ADAMTS5 (0.43) | ADAMTS5RORCPSEN1PSEN2APH1B | |
| SCHEMBL5034688 | 0.81 | MMP2 (0.41) | ADAMTS5RORCMMP2MMP9MMP1 | |
| SCHEMBL7533987 | 0.78 | MMP2 (0.42) | ADAMTS5RORCPSEN1PSEN2APH1B | |
| SCHEMBL5033278 | 0.78 | ADAMTS5 (0.42) | ADAMTS5RORCMMP2MMP9MEN1 | |
| SCHEMBL4900709 | 0.77 | ADAMTS5 (0.41) | ADAMTS5RORCPSEN1PSEN2APH1B | |
| SCHEMBL5033295 | 0.77 | ADAMTS5 (0.43) | ADAMTS5RORCMMP2MMP9MEN1 | |
| SCHEMBL4900721 | 0.77 | ADAMTS5 (0.41) | ADAMTS5RORCPSEN1PSEN2APH1B | |
| SCHEMBL29401127 | 0.70 | POLB (0.40) | MEN1KMT2AMMP1MMP8MMP13 | |
| SCHEMBL4892574 | 0.70 | MMP2 (0.52) | ADAMTS5MMP2MMP9CA12CA1 | |
| SCHEMBL4892559 | 0.70 | MMP2 (0.52) | ADAMTS5MMP2MMP9CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |