Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 6/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033278 | 0.88 | ADAMTS5 (0.42) | ADAMTS5MMP2MMP9RORCMEN1 | |
| SCHEMBL5033291 | 0.78 | ADAMTS5 (0.43) | ADAMTS5MMP2MMP9RORCMEN1 | |
| SCHEMBL5033274 | 0.77 | ADAMTS5 (0.44) | ADAMTS5MMP2MMP9RORCMEN1 | |
| SCHEMBL5034689 | 0.77 | MMP2 (0.36) | ADAMTS5MMP2MMP9MMP1MMP3 | |
| SCHEMBL4891268 | 0.70 | ADAMTS5 (0.38) | ADAMTS5MMP2MMP9RORCMEN1 | |
| SCHEMBL4900709 | 0.70 | ADAMTS5 (0.41) | ADAMTS5MMP2MMP9RORCMEN1 | |
| SCHEMBL4900721 | 0.70 | ADAMTS5 (0.41) | ADAMTS5MMP2MMP9RORCMEN1 | |
| SCHEMBL7874061 | 0.69 | ALDH1A1 (0.58) | MEN1KMT2AMMP1 | |
| SCHEMBL9709587 | 0.68 | PSEN1 (0.35) | CA2CA12CA1CA14 | |
| SCHEMBL5034688 | 0.68 | MMP2 (0.41) | ADAMTS5MMP2MMP9RORCMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |