SCHEMBL5033731 — predicted protein targets

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	APLNR	P35414	2/20	0.36

▸	MAP2K1	Q02750	13/20	0.35

▸	MAP2K2	P36507	2/20	0.35

▸	EGFR	P00533	3/20	0.34

▸	KDR	P35968	3/20	0.34

▸	AAK1	Q2M2I8	1/20	0.33

▸	NPC1	O15118	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5559975	0.78	MAP2K1 (0.48)	MAP2K1MAP2K2EGFRKDRNPC1
SCHEMBL5028995	0.74	MAP2K2 (0.39)	MAP2K1MAP2K2NPC1
SCHEMBL392036	0.71	MAP2K1 (0.45)	MAP2K1MAP2K2NPC1
SCHEMBL388633	0.70	MAP2K1 (0.52)	MAP2K1MAP2K2NPC1
SCHEMBL393001	0.70	MAP2K1 (0.47)	MAP2K1MAP2K2
SCHEMBL393000	0.70	MAP2K1 (0.47)	MAP2K1MAP2K2
SCHEMBL5029045	0.68	MAP2K1 (0.40)	MAP2K1MAP2K2NPC1
SCHEMBL5554883	0.67	MAP2K1 (0.47)	MAP2K1MAP2K2
SCHEMBL393632	0.67	MAP2K1 (0.54)	MAP2K1MAP2K2
SCHEMBL393633	0.67	MAP2K1 (0.54)	MAP2K1MAP2K2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1922307-A2	HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF	Array Biopharma, Inc. (US)	2008-05-21	—	—	EP	disclosed
WO-2007044084-A2	HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF	ARRAY BIOPHARMA INC. (US)	2007-04-19	—	—	WO	disclosed