Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 12/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29425412 | 0.81 | MAP2K1 (0.60) | MAP2K1MAP2K2 | |
| SCHEMBL7264679 | 0.78 | MAP2K1 (0.40) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL31354784 | 0.76 | MAP2K1 (0.55) | MAP2K1MAP2K2 | |
| SCHEMBL31354764 | 0.75 | MAP2K1 (0.50) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL1580463 | 0.74 | MAP2K1 (0.67) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL5031244 | 0.74 | MAP2K1 (0.40) | MAP2K1MAP2K2 | |
| SCHEMBL5031221 | 0.74 | MAP2K1 (0.42) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL1776186 | 0.73 | MAP2K1 (0.71) | MAP2K1MAP2K2 | |
| SCHEMBL5035606 | 0.73 | MAP2K1 (0.46) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL5029045 | 0.72 | MAP2K1 (0.40) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511614-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | claimed |
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |