Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035258 | 0.85 | ALDH1A1 (0.51) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5034910 | 0.82 | KDM4E (0.56) | L3MBTL1KDM4EALDH1A1SMN1; SMN2ENPP3 | |
| SCHEMBL5032668 | 0.77 | ALDH1A1 (0.50) | L3MBTL1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5035917 | 0.76 | MAPK1 (0.55) | MAPK1L3MBTL1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10282879 | 0.75 | ALDH1A1 (0.56) | L3MBTL1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1939267 | 0.73 | KDM4E (0.38) | L3MBTL1KDM4EALDH1A1SMN1; SMN2ENPP3 | |
| SCHEMBL1805549 | 0.73 | MAPK1 (0.55) | MAPK1L3MBTL1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL4959356 | 0.73 | MAPK1 (0.55) | MAPK1L3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1805024 | 0.73 | MAPK1 (0.55) | MAPK1L3MBTL1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20078764 | 0.72 | ALDH1A1 (0.58) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |