Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16897689 | 0.80 | AKR1B1 (0.34) | AKR1B1LMNAALDH1A1 | |
| SCHEMBL11424155 | 0.75 | LMNA (0.42) | AKR1B1LMNA | |
| SCHEMBL640184 | 0.75 | LMNA (0.42) | AKR1B1LMNA | |
| SCHEMBL122818 | 0.75 | LMNA (0.42) | AKR1B1LMNA | |
| SCHEMBL3073599 | 0.73 | LMNA (0.46) | AKR1B1LMNA | |
| SCHEMBL319408 | 0.73 | LMNA (0.46) | AKR1B1LMNA | |
| SCHEMBL517269 | 0.73 | LMNA (0.46) | AKR1B1LMNA | |
| SCHEMBL2635052 | 0.73 | LMNA (0.46) | AKR1B1LMNA | |
| SCHEMBL3640558 | 0.72 | AKR1B1 (0.39) | AKR1B1LMNAALDH1A1 | |
| SCHEMBL769450 | 0.72 | MPI (0.37) | AKR1B1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896040-A2 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | Threshold Pharmaceuticals, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007002931-A2 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |