Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039290 | 0.89 | AOC3 (0.42) | KMT2ARAB9ASMN1; SMN2ALDH1A1BCHE | |
| SCHEMBL29094810 | 0.78 | TRPA1 (0.49) | LTA4HKMT2ARAB9ASIGMAR1ALDH1A1 | |
| SCHEMBL5131445 | 0.73 | KCNA3 (0.44) | LTA4HNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5046082 | 0.73 | NPC1 (0.37) | TSHRKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3334310 | 0.72 | TSHR (0.48) | TSHRKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL3334314 | 0.72 | TSHR (0.48) | TSHRKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL5040616 | 0.71 | MAOB (0.38) | TSHRKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29094830 | 0.71 | TP53 (0.41) | TSHRKMT2AALDH1A1MEN1BCHE | |
| SCHEMBL29094798 | 0.71 | CYP19A1 (0.43) | LTA4HTSHRKMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL4777209 | 0.70 | LTA4H (0.55) | LTA4HTSHRNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677745-A4 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS INC (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1677745-A2 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | Renovis, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| US-20050192281-A1 | Nitrone compounds, prodrugs and pharmaceuticals compositons of the same to treat human disorders | RENOVIS, INC. | 2005-09-01 | — | — | US | disclosed |
| WO-2005037208-A2 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192281-A1 | Nitrone compounds, prodrugs and pharmaceuticals compositons of the same to treat human disorders | NLN, NQO1, OPRL1 | LTA4H 892/4885TSHR 3020/4885KMT2A 3770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.