Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042504 | 0.82 | PTGES (0.37) | KDM4EALDH1A1HPGDHTR4HTR3A | |
| SCHEMBL6773455 | 0.82 | HTR4 (0.50) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL8287809 | 0.79 | HTR4 (0.46) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL18934421 | 0.79 | PTGES (0.39) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8500146 | 0.78 | HTR4 (0.35) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL8287812 | 0.76 | HTR4 (0.43) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL2431237 | 0.76 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL8496525 | 0.76 | HTR4 (0.42) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7749960 | 0.76 | HTR4 (0.64) | KDM4EALDH1A1HPGDHTR4HTR2C | |
| SCHEMBL10044410 | 0.75 | ALDH1A1 (0.39) | ALDH1A1CYP1A2CYP3A4CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812321-B1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2008-01-23 | — | — | EP | disclosed |
| US-5854261-A | Prokinetic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-29 | — | — | US | disclosed |
| EP-0812321-A1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026937-A1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-06 | — | — | WO | disclosed |