Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425764 | 0.93 | GAA (0.53) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL14964741 | 0.85 | CHRM1 (0.59) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL21944817 | 0.85 | CHRM1 (0.59) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL4631015 | 0.85 | GAA (0.59) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL4441606 | 0.85 | LMNA (0.56) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL23041797 | 0.84 | GAA (0.62) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL18933177 | 0.83 | GAA (0.41) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL5310934 | 0.83 | RAB9A (0.47) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL18933102 | 0.82 | GAA (0.41) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL30674449 | 0.81 | EPHX1 (0.42) | GAAL3MBTL1THRBATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114773256-B | Synthesis method of 4-cyano piperidine | 中国农业大学 | 2024-05-03 | — | — | CN | disclosed |
| CN-114773256-A | Synthetic method of 4-cyanopiperidine | 中国农业大学 | 2022-07-22 | — | — | CN | disclosed |
| EP-3150578-B1 | NOVEL PYRROLIDINE COMPOUND AND APPLICATION AS MELANOCORTIN RECEPTOR AGONIST | MITSUBISHI TANABE PHARMA CORP (JP) | 2020-10-14 | — | — | EP | disclosed |
| EP-2758389-B1 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-3150578-A1 | NOVEL PYRROLIDINE COMPOUND AND APPLICATION AS MELANOCORTIN RECEPTOR AGONIST | Mitsubishi Tanabe Pharma Corporation (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-0812321-B1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2008-01-23 | — | — | EP | disclosed |
| EP-0892802-B1 | SPIRO(CYCLOPENT(B)INDOLE-PIPERIDINES) AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | AVENTIS PHARMA INC (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6479501-B2 | COGNITION ACTIVATORS; ANTIDEPRESSANTS | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| US-20020004601-A1 | Spiro[cyclopent[b]indole-piperidines] | HOECHST MARION ROUSSEL, INC. | 2002-01-10 | — | — | US | disclosed |
| US-6229014-B1 | 8-AZASPIRO(4.5)DECANE-1-ONE; ANTIDEPRESSANTS AND TREATMENT OF PSYCHOLIGICAL DISORDERS, SPECIFICALLY MEMORY LOSS | HOECHST MARION ROUSSEL, INC. (FR) | 2001-05-08 | — | — | US | disclosed |
| US-6156901-A | Spiro[cyclopent[b]indole-piperidines] | HOECHST MARION ROUSSEL, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| US-5986097-A | ENANTIOMORPHS, COGNITION ACTIVATORS, AZHEIMER'S DISEASE AND ENZYME INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0892802-A1 | SPIRO(CYCLOPENT(B)INDOLE-PIPERIDINES) AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-27 | — | — | EP | disclosed |
| US-5854261-A | Prokinetic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-29 | — | — | US | disclosed |
| US-5756743-A | USEFUL IN TREATING MEMORY DYSFUNCTION AND DEPRESSION | HOECHST MARION ROUSSEL INC. (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0812321-A1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-12-17 | — | — | EP | disclosed |
| WO-1997037992-A2 | SPIRO[CYCLOPENT[B]INDOLE-PIPERIDINES] AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-16 | — | — | WO | disclosed |
| WO-1996026937-A1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020004601-A1 | Spiro[cyclopent[b]indole-piperidines] | CAMK2B, GRIN2B, HTR2B | GAA 4234/4885L3MBTL1 3519/4885THRB 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.