Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 9/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032593 | 0.92 | THRB (0.41) | KDM4EKMT2AMAPTKIF18AALDH1A1 | |
| SCHEMBL5041073 | 0.91 | MAPT (0.53) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5036059 | 0.90 | KDM4E (0.47) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5032681 | 0.90 | KDM4E (0.47) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5039141 | 0.89 | KDM4E (0.49) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5041389 | 0.89 | KDM4E (0.46) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5039082 | 0.87 | KDM4E (0.49) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5034925 | 0.85 | KDM4E (0.48) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5041451 | 0.84 | MAPK1 (0.47) | KDM4EKMT2AHTTMAPTMAPK1 | |
| SCHEMBL5035287 | 0.83 | KDM4E (0.49) | KDM4EKMT2AHTTMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |