Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | CHKA | P35790 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.51 |
| ▸ | NCF1 | P14598 | 3/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29455010 | 1.00 | PKM (0.68) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL1043251 | 0.86 | NCF1 (0.70) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL29455008 | 0.86 | MEN1 (0.60) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL30058999 | 0.86 | NCF1 (0.70) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL1042082 | 0.85 | NCF1 (0.68) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL1042083 | 0.85 | NCF1 (0.68) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL31167362 | 0.83 | MEN1 (0.56) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL28972104 | 0.83 | DRD3 (0.72) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL30060911 | 0.83 | MEN1 (0.56) | PKMALOX15CASP1HSD17B10CHKA | |
| SCHEMBL5025316 | 0.81 | PKM (0.68) | PKMALOX15CASP1HSD17B10CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395564-B1 | QUINOLINE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y RECEPTOR | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | disclosed |
| US-20050049413-A1 | Quinoline derivatives | MUELLER WERNER (CH) | 2005-03-03 | — | — | US | disclosed |
| US-6818767-B2 | NEUROPEPTIDE Y (NPY) ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF ARTHRITIS, CARDIOVASCULAR DISEASES, DIABETES, RENAL FAILURE, EATING DISORDERS, OR OBESITY | HOFFMANN-LA ROCHE INC. | 2004-11-16 | — | — | US | disclosed |
| US-20020198194-A1 | Quinoline derivatives | HOFFMANN-LA ROCHE INC. | 2002-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198194-A1 | Quinoline derivatives | NPY2R, NPY1R, NPY4R | PKM 4348/4885ALOX15 2676/4885CASP1 1920/4885 |
| US-20050049413-A1 | Quinoline derivatives | NPY2R, NPY1R, NPY4R | PKM 4348/4885ALOX15 2676/4885CASP1 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.