Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PON1 | P27169 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | FDPS | P14324 | 15/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17752921 | 0.99 | MEN1 (0.43) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Iodide SCHEMBL29954380 | 0.97 | MEN1 (0.42) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL503784 | 0.94 | MEN1 (0.42) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30639258 | 0.93 | FDPS (0.37) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30360159 | 0.93 | MEN1 (0.35) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Iodide SCHEMBL29954174 | 0.92 | MEN1 (0.49) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| SCHEMBL17424587 | 0.88 | MEN1 (0.38) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL15561445 | 0.87 | PON1 (0.41) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL503685 | 0.87 | FDPS (0.35) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| SCHEMBL31096257 | 0.86 | MEN1 (0.42) | PON1MEN1HSP90AA1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8739977-B2 | Composite semipermeable membrane and method for producing the same | TORAY INDUSTRIES, INC. (JP) | 2014-06-03 | — | — | US | disclosed |
| EP-2415515-A1 | COMPOSITE SEMIPERMEABLE MEMBRANE AND PROCESS FOR PRODUCTION THEREOF | Toray Industries, Inc. (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20120024778-A1 | COMPOSITE SEMIPERMEABLE MEMBRANE AND METHOD FOR PRODUCING THE SAME | TORAY INDUSTRIES, INC. (JP) | 2012-02-02 | — | — | US | disclosed |