SCHEMBL5038019

SCHEMBL5038019

O=CCNC=CCCCc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 10/20 0.44
NAMPT P43490 1/20 0.40
ADH1B P00325 1/20 0.39
ADH1C P00326 1/20 0.39
ADH1A P07327 1/20 0.39
ADH7 P40394 1/20 0.39
HDAC3 O15379 2/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC2 Q92769 2/20 0.38
HDAC8 Q9BY41 2/20 0.38
HDAC6 Q9UBN7 2/20 0.38
HDAC5 Q9UQL6 2/20 0.38
MAPK1 P28482 1/20 0.38
ADRA1A P35348 1/20 0.38
HDAC4 P56524 1/20 0.38
SLC6A3 Q01959 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL66826 0.80 SIGMAR1 (0.54) SIGMAR1ADH1BADH1CADH1AADH7
SCHEMBL11050330 0.78 SIGMAR1 (0.52) SIGMAR1ADH1BADH1CADH1AADH7
SCHEMBL11050654 0.78 SIGMAR1 (0.52) SIGMAR1ADH1BADH1CADH1AADH7
SCHEMBL11057347 0.78 SIGMAR1 (0.52) SIGMAR1ADH1BADH1CADH1AADH7
SCHEMBL6014516 0.76 SIGMAR1 (0.50) SIGMAR1ADH1BADH1CADH1AADH7
SCHEMBL6014514 0.76 SIGMAR1 (0.50) SIGMAR1ADH1BADH1CADH1AADH7
SCHEMBL17715334 0.75 ADH1B (0.46) SIGMAR1NAMPTADH1BADH1CADH1A
SCHEMBL6014388 0.75 L3MBTL1 (0.50) SIGMAR1
SCHEMBL6014392 0.75 L3MBTL1 (0.50) SIGMAR1
SCHEMBL6014624 0.75 SIGMAR1 (0.51) SIGMAR1ADH1BADH1CADH1AADH7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1889903-A1 Biocatalysts with amine acylase activity Novartis AG (CH) 2008-02-20 EP disclosed
EP-0954571-B1 BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY NOVARTIS AG (CH) 2007-08-29 EP disclosed
US-6235516-B1 FROM RHODOCOCCUS GLOBERULUS, RHODOCOCCUS EQUI OR ARTHROBACTER AURESCENS NOVARTIS AG (CH) 2001-05-22 US disclosed
EP-0954571-A1 BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY Novartis AG (CH) 1999-11-10 EP disclosed
WO-1997041214-A1 BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY NOVARTIS AG (CH) 1997-11-06 WO disclosed