Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15219217 | 0.92 | KDM4E (0.57) | MAPK1TSHRALDH1A1L3MBTL1TDP1 | |
| SCHEMBL16667635 | 0.90 | KDM4E (0.59) | MAPK1TSHRALDH1A1HRH3L3MBTL1 | |
| SCHEMBL16669059 | 0.90 | KDM4E (0.59) | MAPK1TSHRALDH1A1HRH3L3MBTL1 | |
| SCHEMBL1729519 | 0.88 | MAPK1 (0.75) | MAPK1TSHRALDH1A1HRH3NPSR1 | |
| SCHEMBL15295214 | 0.84 | ALDH1A1 (0.48) | MAPK1TSHRALDH1A1HRH3APP | |
| SCHEMBL3920395 | 0.82 | MAPK1 (0.68) | MAPK1TSHRALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL10186609 | 0.82 | MAPK1 (0.68) | MAPK1TSHRALDH1A1NPSR1L3MBTL1 | |
| 1-Methoxy-3-Propoxybenzene SCHEMBL791921 | 0.82 | MAPK1 (0.62) | MAPK1TSHRALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL10597796 | 0.82 | MAPK1 (0.68) | MAPK1TSHRALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL7922018 | 0.82 | KDM4E (0.49) | MAPK1TSHRALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1880995-A1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | Eisai R&D Management Co., Ltd. (JP) | 2008-01-23 | — | — | EP | claimed |
| EP-1880995-B1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | EISAI R&D MAN CO LTD (JP) | 2011-12-21 | — | — | EP | disclosed |
| EP-1880995-A1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | Eisai R&D Management Co., Ltd. (JP) | 2008-01-23 | — | — | EP | disclosed |
| EP-0279150-A1 | 5-Oxy-substituted-3-aminochroman compounds, processes for their preparation, pharmaceutical compositions containing them and methods of treatment therewith | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1988-08-24 | — | — | EP | disclosed |
| WO-1988004654-A1 | 5-HYDROXY-3-AMINOCHROMAN COMPOUNDS, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF TREATMENT THEREWITH | Astra Läkemedel Aktiebolag (SE) | 1988-06-30 | — | — | WO | disclosed |