Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545796 | 0.82 | NOTUM (0.41) | MAPTSMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL5585114 | 0.79 | NISCH (0.37) | MAPTSMN1; SMN2ALDH1A1HSD17B10NPC1 | |
| SCHEMBL2253193 | 0.76 | MAPK14 (0.38) | MAPTSMN1; SMN2MAPK1ALDH1A1ALOX15 | |
| SCHEMBL3126530 | 0.75 | SIGMAR1 (0.46) | SMN1; SMN2TSHRHSD17B10NPC1RAB9A | |
| SCHEMBL9360528 | 0.74 | KIF11 (0.42) | SMN1; SMN2ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL5584331 | 0.74 | NISCH (0.42) | MAPTSMN1; SMN2MAPK1ALDH1A1NPC1 | |
| SCHEMBL1366657 | 0.74 | NISCH (0.42) | MAPTSMN1; SMN2ALDH1A1HSD17B10NPC1 | |
| SCHEMBL240095 | 0.74 | SIGMAR1 (0.42) | SMN1; SMN2MAPK1ALDH1A1TSHRNPC1 | |
| SCHEMBL4261253 | 0.71 | PTGS2 (0.46) | — | |
| SCHEMBL1363974 | 0.71 | NISCH (0.45) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |