Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035170 | 0.88 | CYP3A4 (0.36) | CYP3A4FLT1FLT4KDRIRAK4 | |
| SCHEMBL5034781 | 0.87 | CYP3A4 (0.42) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5032683 | 0.85 | CYP3A4 (0.37) | CYP3A4FLT1FLT4KDRIRAK4 | |
| SCHEMBL5035001 | 0.85 | CYP3A4 (0.41) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5035233 | 0.84 | CYP3A4 (0.38) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5036081 | 0.81 | CYP3A4 (0.35) | CYP3A4FLT1FLT4KDRIRAK4 | |
| SCHEMBL14190190 | 0.79 | FLT1 (0.41) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5032642 | 0.78 | CYP3A4 (0.41) | CYP3A4GAANPSR1 | |
| SCHEMBL5035234 | 0.78 | ALDH1A1 (0.41) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5032512 | 0.77 | CYP3A4 (0.40) | CYP3A4FLT1FLT4KDRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |