Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048897 | 0.82 | ACACB (0.35) | ACACBMTNR1AFFAR1 | |
| SCHEMBL4981880 | 0.80 | ACACB (0.42) | ACACBPTGESFFAR1CYP1A2CYP3A4 | |
| SCHEMBL1854016 | 0.79 | PTGES (0.35) | ACACBMTNR1APTGESFFAR1 | |
| SCHEMBL1852638 | 0.79 | PTGES (0.42) | ACACBPTPN11MTNR1APTGESFFAR1 | |
| SCHEMBL4966603 | 0.78 | PLK1 (0.43) | ACACBPTGESFFAR1UTS2R | |
| SCHEMBL4671672 | 0.77 | FFAR1 (0.38) | ACACBPTPN11MTNR1APTGESFFAR1 | |
| SCHEMBL4974276 | 0.75 | MTNR1A (0.32) | ACACBMTNR1AFFAR1 | |
| SCHEMBL1852713 | 0.73 | ACACB (0.51) | ACACB | |
| SCHEMBL5140004 | 0.73 | PTGES (0.35) | ACACBMTNR1APTGESFFAR1 | |
| SCHEMBL1854015 | 0.73 | PTGES (0.38) | ACACBMTNR1APTGESFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |