Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048720 | 0.86 | PPARG (0.50) | PPARGPPARAEPHX2MAPK14NPC1 | |
| SCHEMBL5049271 | 0.84 | EPHX2 (0.46) | PPARGPPARAEPHX2MAPK14TRPV1 | |
| SCHEMBL5046020 | 0.79 | PPARG (0.53) | PPARGPPARAEPHX2MAPK14TRPV1 | |
| SCHEMBL1851475 | 0.78 | MAPK14 (0.48) | PPARGPPARAEPHX2MAPK14NPC1 | |
| SCHEMBL4197091 | 0.76 | TRPV1 (0.66) | EPHX2NPC1RAB9ATRPV1HDAC3 | |
| SCHEMBL5040010 | 0.72 | FFAR1 (0.47) | PPARGPPARAEPHX2MAPK14HPGD | |
| SCHEMBL5044185 | 0.71 | FFAR1 (0.46) | PPARGPPARAEPHX2MAPK14HPGD | |
| SCHEMBL5040011 | 0.71 | FFAR1 (0.48) | MAPK14HPGDTRPV1HDAC1LMNA | |
| SCHEMBL12338972 | 0.70 | HDAC3 (0.67) | PPARGRAB9ATRPV1HDAC3HDAC1 | |
| SCHEMBL5044189 | 0.70 | FFAR1 (0.47) | MAPK14HPGDTRPV1HDAC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |