Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044857 | 0.94 | MAPK14 (0.51) | ALDH1A1SMN1; SMN2HTTMAPK14HPGD | |
| SCHEMBL5040011 | 0.89 | FFAR1 (0.48) | FFAR1ALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL5044185 | 0.88 | FFAR1 (0.46) | FFAR1ALDH1A1SMN1; SMN2MAPK14HPGD | |
| SCHEMBL6023308 | 0.88 | MAPK14 (0.51) | MAPK14HPGDLMNATRPV1HDAC1 | |
| SCHEMBL1855452 | 0.87 | PTGES (0.42) | FFAR1ALDH1A1SMN1; SMN2MAPK14HPGD | |
| SCHEMBL5044851 | 0.83 | MAPK14 (0.49) | ALDH1A1SMN1; SMN2HTTMAPK14HPGD | |
| SCHEMBL1859045 | 0.82 | STAT3 (0.46) | ALDH1A1SMN1; SMN2HTTMAPK14HPGD | |
| SCHEMBL5047479 | 0.82 | MAPK14 (0.47) | ALDH1A1SMN1; SMN2HTTMAPK14HPGD | |
| SCHEMBL5040010 | 0.81 | FFAR1 (0.47) | FFAR1ALDH1A1MAPK14HPGDLMNA | |
| SCHEMBL1853566 | 0.81 | LMNA (0.44) | FFAR1ALDH1A1SMN1; SMN2HTTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |