Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.53 |
| ▸ | PPARA | Q07869 | 4/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | MTTP | P55157 | 3/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049271 | 0.90 | EPHX2 (0.46) | PPARGPPARAEPHX2LSSTRPV1 | |
| SCHEMBL1856434 | 0.79 | MLYCD (0.50) | PPARGPPARAEPHX2HDAC1PPARD | |
| SCHEMBL5040079 | 0.79 | PPARG (0.51) | PPARGPPARAEPHX2TRPV1HDAC1 | |
| SCHEMBL4321965 | 0.78 | LSS (0.57) | PPARGPPARAEPHX2LSSTRPV1 | |
| SCHEMBL5047553 | 0.76 | TAAR1 (0.39) | PPARGPPARAEPHX2 | |
| SCHEMBL6022101 | 0.74 | PPARG (0.46) | PPARGPPARAEPHX2LSSTRPV1 | |
| SCHEMBL5047430 | 0.74 | HDAC8 (0.53) | HDAC1 | |
| SCHEMBL4197091 | 0.73 | TRPV1 (0.66) | EPHX2TRPV1HDAC1PLK1RARB | |
| SCHEMBL6022076 | 0.73 | TRPV1 (0.59) | EPHX2TRPV1HDAC1PLK1RARB | |
| SCHEMBL5048860 | 0.73 | MLYCD (0.53) | PPARGPPARAEPHX2HDAC1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |