Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ATP4A | P20648 | 2/20 | 0.32 |
| ▸ | ATP4B | P51164 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040385 | 1.00 | KDM4E (0.34) | KDM4EGAANPSR1ATP4AATP4B | |
| SCHEMBL5042223 | 0.78 | ATP4A (0.35) | KDM4EATP4AATP4BALOX15MAPT | |
| SCHEMBL5041462 | 0.74 | ELANE (0.38) | KDM4ENPSR1ATP4AATP4BALDH1A1 | |
| SCHEMBL6672735 | 0.73 | ELANE (0.37) | KDM4EATP4AATP4BALDH1A1TSHR | |
| SCHEMBL5744048 | 0.73 | ELANE (0.37) | KDM4EATP4AATP4BALDH1A1TSHR | |
| SCHEMBL7107773 | 0.69 | ELANE (0.35) | KDM4EATP4AATP4BALOX15MAPT | |
| SCHEMBL6529295 | 0.69 | ELANE (0.35) | KDM4EATP4AATP4BALOX15MAPT | |
| SCHEMBL5044812 | 0.69 | KIF11 (0.38) | KDM4EGAAATP4AATP4B | |
| SCHEMBL5746631 | 0.69 | ELANE (0.34) | KDM4EATP4AATP4BALDH1A1ELANE | |
| SCHEMBL4972810 | 0.66 | ELANE (0.32) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314935-B2 | Tricyclic n-acyl compounds | ALTANA PHARMA AG (DE) | 2008-01-01 | — | — | US | disclosed |
| EP-1414821-B1 | TRICYCLIC EPOXIDES | ALTANA PHARMA AG (DE) | 2006-08-16 | — | — | EP | disclosed |
| US-6927292-B2 | Tricyclic epoxides | ALTANA PHARMA AG (DE) | 2005-08-09 | — | — | US | disclosed |
| US-20050148618-A1 | Tricyclic n-acyl compounds | ALTANA PHARMA AG (DE) | 2005-07-07 | — | — | US | disclosed |
| EP-1476445-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA Pharma AG (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-20040176597-A1 | Tricyclic epoxides | ALTANA PHARMA AG (DE) | 2004-09-09 | — | — | US | disclosed |
| WO-2003068774-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA PHARMA AG (DE) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148618-A1 | Tricyclic n-acyl compounds | NAT1, AADAC, CYP1B1 | KDM4E 2624/4885GAA 229/4885NPSR1 1489/4885 |
| US-20040176597-A1 | Tricyclic epoxides | VKORC1, CYP2E1, CYP1A2 | KDM4E 1288/4885GAA 798/4885NPSR1 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.