Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.78 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.78 |
| ▸ | F2 | P00734 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL5634066 | 1.00 | PRSS1 (0.78) | PRSS1TPSAB1F2 | |
| Nitric Acid SCHEMBL5634370 | 1.00 | PRSS1 (0.78) | PRSS1TPSAB1F2 | |
| SCHEMBL4314345 | 0.95 | PRSS1 (0.70) | PRSS1TPSAB1F2 | |
| SCHEMBL5634690 | 0.95 | PRSS1 (0.70) | PRSS1TPSAB1F2 | |
| SCHEMBL20817059 | 0.95 | PRSS1 (0.70) | PRSS1TPSAB1F2 | |
| SCHEMBL5634902 | 0.95 | PRSS1 (0.70) | PRSS1TPSAB1F2 | |
| SCHEMBL8306067 | 0.95 | PRSS1 (0.70) | PRSS1TPSAB1F2 | |
| SCHEMBL4314363 | 0.95 | PRSS1 (0.70) | PRSS1TPSAB1F2 | |
| Sulfuric Acid SCHEMBL5045181 | 0.93 | PRSS1 (0.67) | PRSS1TPSAB1F2 | |
| SCHEMBL5634073 | 0.88 | PRSS1 (0.61) | PRSS1TPSAB1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660493-B1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA NV (BE) | 2008-10-08 | — | — | EP | disclosed |
| US-7205384-B2 | Process for preparing peptidyl heterocyclic ketone derivatives | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | CMA1, TPSB2, TPSAB1 | PRSS1 30/4885TPSAB1 3/4885F2 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.