SCHEMBL5040795

SCHEMBL5040795

CC(Cc1ccccc1)OCC=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
SIGMAR1 Q99720 4/20 0.45
SLC6A2 P23975 2/20 0.45
MAOA P21397 1/20 0.45
SLC6A4 P31645 1/20 0.45
SLC6A3 Q01959 1/20 0.45
CYP2A6 P11509 1/20 0.45
ADORA2A P29274 1/20 0.45
ADORA1 P30542 1/20 0.45
EPHX1 P07099 1/20 0.44
SLC18A2 Q05940 1/20 0.42
CYP2D6 P10635 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
TRPA1 O75762 1/20 0.41
CTSK P43235 2/20 0.40
CTSL P07711 1/20 0.40
CTSB P07858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17429777 0.80 TAAR1 (0.42) TAAR1MEN1KMT2ASIGMAR1SLC6A2
SCHEMBL3678022 0.78 TAAR1 (0.55) TAAR1MEN1KMT2ASIGMAR1SLC6A2
SCHEMBL5322350 0.77 SRR (0.59)
SCHEMBL7301799 0.77 SRR (0.59)
SCHEMBL2700588 0.75 SIGMAR1 (0.52) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL2554445 0.75 TAAR1 (0.52) TAAR1MEN1KMT2ASIGMAR1SLC6A2
SCHEMBL2322250 0.74 HCAR2 (0.43) TAAR1MEN1KMT2ACYP2D6TRPA1
SCHEMBL17636071 0.74 TAAR1 (0.44) TAAR1MEN1KMT2ASIGMAR1SLC6A2
SCHEMBL16416739 0.74 SRR (0.51) EPHX1
SCHEMBL3627334 0.74 TAAR1 (0.56) TAAR1SIGMAR1SLC6A2MAOASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1677745-A4 NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS RENOVIS INC (US) 2008-10-22 EP disclosed
EP-1677745-A2 NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS Renovis, Inc. (US) 2006-07-12 EP disclosed
WO-2005037208-A2 NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS RENOVIS, INC. (US) 2005-04-28 WO disclosed
EP-1465897-A2 PROCESS FOR PREPARING PROTEASE INHIBITOR INTERMEDIATES SmithKline Beecham Corporation (US) 2004-10-13 EP disclosed
WO-2003024974-A2 PROCESS FOR PREPARING PROTEASE INHIBITOR INTERMEDIATES SMITHKLINE BEECHAM CORPORATION (US) 2003-03-27 WO disclosed