Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 8/20 | 0.44 |
| ▸ | CHRNA4 known ✓ | P43681 | 8/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4827701 | 0.84 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL5038358 | 0.83 | CHRNB2 (0.67) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5034151 | 0.82 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL652029 | 0.80 | CHRNB2 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL652028 | 0.80 | CHRNB2 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4823839 | 0.80 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL4825516 | 0.79 | GPR119 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL4826229 | 0.78 | CHRNB2 (0.41) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL4827568 | 0.78 | CHRNB2 (0.41) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL4826782 | 0.78 | CHRNB2 (0.41) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359152-B1 | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands | ABBOTT LAB (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7265115-B2 | Diazabicyclic CNS active agents | ABBOTT LABORATORIES (US) | 2007-09-04 | — | — | US | disclosed |
| US-20030225268-A1 | Diazabicyclic CNS active agents | ABBVIE INC. | 2003-12-04 | — | — | US | disclosed |
| EP-1359152-A2 | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands | ABBOTT LABORATORIES (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-1147112-B1 | DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ABBOTT LAB (US) | 2003-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225268-A1 | Diazabicyclic CNS active agents | GABRE, GRIN1, CNTN1 | CHRNB2 29/4885CHRNA4 14/4885CHRNB4 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.