Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035282 | 0.92 | CA2 (0.46) | — | |
| SCHEMBL5035097 | 0.89 | LMNA (0.43) | KCNH2RXFP1KDM4EHTTKMT2A | |
| SCHEMBL5035013 | 0.86 | KDM4E (0.46) | NTRK1RXFP1KDM4EHTTKMT2A | |
| SCHEMBL5032666 | 0.86 | NTRK1 (0.44) | NTRK1EPHX2RXFP1KDM4EHTT | |
| SCHEMBL5041227 | 0.85 | RXFP1 (0.48) | NTRK1KCNH2RXFP1KDM4EHTT | |
| SCHEMBL5039150 | 0.84 | KDM4E (0.54) | NTRK1KDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5035007 | 0.83 | NTRK1 (0.41) | NTRK1EPHX2RXFP1KDM4EHTT | |
| SCHEMBL5035086 | 0.80 | CA2 (0.51) | KMT2AMAPT | |
| SCHEMBL5041442 | 0.79 | KDM4E (0.45) | RXFP1KDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5035278 | 0.79 | CA2 (0.44) | KDM4EHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |