Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876364 | 0.86 | ROCK1 (0.58) | ROCK1TRPA1MAPK14EPAS1NOS1 | |
| SCHEMBL16004752 | 0.83 | ROCK1 (0.43) | ROCK1TRPA1EPAS1CTNNB1WNT3A | |
| SCHEMBL378733 | 0.83 | AR (0.46) | ROCK1TRPA1EPAS1AR | |
| SCHEMBL2880077 | 0.81 | MAPT (0.63) | ROCK1TRPA1HSPB1EPAS1NOS1 | |
| SCHEMBL2884889 | 0.79 | ROCK1 (0.56) | ROCK1TRPA1EPAS1RAB9AKDM4E | |
| SCHEMBL28707122 | 0.79 | NOS1 (0.46) | ROCK1TRPA1CTNNB1WNT3ANOS1 | |
| SCHEMBL20155327 | 0.79 | TRPA1 (0.45) | TRPA1MAPK14CTNNB1WNT3A | |
| SCHEMBL8331875 | 0.78 | ROCK1 (0.74) | ROCK1ROCK2CDC7 | |
| SCHEMBL20160340 | 0.78 | MAPK14 (0.43) | TRPA1MAPK14NOS1 | |
| SCHEMBL30194137 | 0.78 | AXL (0.48) | TRPA1MAPK14EPAS1NOS1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883404-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006122230-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2006-11-16 | — | — | WO | disclosed |